منابع مشابه
Tumor Microenvironment and Metabolism
The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...].
متن کاملEditorial: Immuno-Metabolism in Tumor Microenvironment
From Hanahan and Weinberg’s original description of six hallmarks of cancer (self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis) (1), it took only 11 years to add in 2011, based on an increasing body of research, two “emerging hallmarks of cancer”: dereg...
متن کاملTumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity
When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates "metabolic checkpoints" ...
متن کاملMolecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the "Warburg effect", commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial ...
متن کاملThe Tumor Microenvironment Modulates Choline and Lipid Metabolism
An increase of cellular phosphocholine (PC) and total choline (tCho)-containing compounds as well as alterations in lipids have been consistently observed in cancer cells and tissue. These metabolic changes are closely related to malignant transformation, invasion, and metastasis. The study of cancer cells in culture plays an important role in understanding mechanisms leading to altered choline...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2017
ISSN: 1422-0067
DOI: 10.3390/ijms18122729